salary$131,580 a year$63 an hour · median pay in the St. Louis, MO-IL area
Lower pay (bottom 10%)$108,340per year
Top pay (top 10%)$164,280per year
Jobs in the area3,430people work this job
Can a nurse practitioner afford St. Louis?
Cheap. Rent of $1,297 a month takes 11.8% of the median nurse practitioner salary. That is under the 30% rule, so one paycheck covers rent comfortably.
Nurse Practitioner pay in similar cities
Other jobs in St. Louis
Registered NurseLicensed Practical NurseNursing AssistantMedical AssistantPharmacistPhysician AssistantDental HygienistElementary School TeacherSoftware DeveloperComputer Systems AnalystAccountantMarket Research AnalystOperations ManagerLawyer
Frequently asked questions
How much does a nurse practitioner make in St. Louis, MO?
The median pay for a nurse practitioner in the St. Louis, MO-IL area is $131,580 a year ($63 an hour). Most earn between $108,340 and $164,280.
Can a nurse practitioner afford to live in St. Louis?
Typical rent of $1,297 a month takes 11.8% of the median nurse practitioner salary, which we rate Cheap.
Source: U.S. Bureau of Labor Statistics, Occupational Employment and Wage Statistics, May 2025, for the St. Louis, MO-IL metro area.